Aldosterone-mediated regulation of Na+, K(+)-ATPase gene expression in adult and neonatal rat cardiocytes.

@article{Ikeda1991AldosteronemediatedRO,
  title={Aldosterone-mediated regulation of Na+, K(+)-ATPase gene expression in adult and neonatal rat cardiocytes.},
  author={Uichi Ikeda and Robert Hyman and Thomas W. Smith and Russell M. Medford},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 18},
  pages={12058-66}
}
By altering the Na+/K+ electrochemical gradient, Na+,K(+)-ATPase activity profoundly influences cardiac cell excitability and contractility. The recent finding of mineralocorticoid hormone receptors in the heart implies that Na+,K(+)-ATPase gene expression, and hence cardiac function, is regulated by aldosterone, a corticosteroid hormone associated with certain forms of hypertension and classically involved in regulating Na+,K(+)-ATPase gene expression and transepithelial Na+ transport in… CONTINUE READING