Aldosterone inhibits endothelial morphogenesis and angiogenesis through the downregulation of vascular endothelial growth factor receptor-2 expression subsequent to peroxisome proliferator-activated receptor gamma.

@article{Fujii2012AldosteroneIE,
  title={Aldosterone inhibits endothelial morphogenesis and angiogenesis through the downregulation of vascular endothelial growth factor receptor-2 expression subsequent to peroxisome proliferator-activated receptor gamma.},
  author={Miki Fujii and Isao Inoki and Makoto Saga and Norihiro Morikawa and Ken-ichiro Arakawa and Satoru Inaba and Kazuaki Yoshioka and Tadashi Konoshita and Isamu Miyamori},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2012},
  volume={129 3-5},
  pages={145-52}
}
Angiogenesis plays a pivotal role in cardiovascular diseases such as ischemic heart disease, limb ischemia and heart failure, and has recently been shown to mediate various biological activities related to the pathogenesis of these diseases. In the present study, we evaluated the role of aldosterone in angiogenesis. Tube formation assay on Matrigel using human umbilical vein endothelial cells (HUVEC) revealed that aldosterone inhibited endothelial morphogenesis in a manner sensitive to… CONTINUE READING

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