Aldosterone induces apoptosis in rat podocytes: role of PI3-K/Akt and p38MAPK signaling pathways.

  title={Aldosterone induces apoptosis in rat podocytes: role of PI3-K/Akt and p38MAPK signaling pathways.},
  author={Cheng Chen and Wei Liang and Junya Jia and Harry van Goor and Pravin C. Singhal and Guohua Ding},
  journal={Nephron. Experimental nephrology},
  volume={113 1},
BACKGROUND Podocytes play a critical role in the pathogenesis of glomerulosclerosis. Increasing evidence suggests that aldosterone (ALD) is involved in the initiation and progression of glomerular damage. It is, however, unknown whether there is a direct injurious effect of ALD on podocytes. Therefore, in the present study, we evaluated the effect of ALD on podocyte apoptosis and studied the role of phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) and p38 mitogen-activated protein kinase (p38MAPK… CONTINUE READING


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Aldosterone and glomerular podocyte injury

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