Aldosterone induces apoptosis in rat podocytes: role of PI3-K/Akt and p38MAPK signaling pathways.

@article{Chen2009AldosteroneIA,
  title={Aldosterone induces apoptosis in rat podocytes: role of PI3-K/Akt and p38MAPK signaling pathways.},
  author={Cheng Chen and Wei Liang and Junya Jia and Harry van Goor and Pravin C. Singhal and Guohua Ding},
  journal={Nephron. Experimental nephrology},
  year={2009},
  volume={113 1},
  pages={e26-34}
}
BACKGROUND Podocytes play a critical role in the pathogenesis of glomerulosclerosis. Increasing evidence suggests that aldosterone (ALD) is involved in the initiation and progression of glomerular damage. It is, however, unknown whether there is a direct injurious effect of ALD on podocytes. Therefore, in the present study, we evaluated the effect of ALD on podocyte apoptosis and studied the role of phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) and p38 mitogen-activated protein kinase (p38MAPK… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Reactive oxygen species-initiated autophagy opposes aldosterone-induced podocyte injury.

American journal of physiology. Renal physiology • 2016
View 1 Excerpt

Potential role of Akt signaling in chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Aldosterone and glomerular podocyte injury

Clinical and Experimental Nephrology • 2008

Similar Papers

Loading similar papers…