Aldosterone-induced apical Na+ and K+ conductances are located predominantly in surface cells in rat distal colon.

@article{Lomax1994AldosteroneinducedAN,
  title={Aldosterone-induced apical Na+ and K+ conductances are located predominantly in surface cells in rat distal colon.},
  author={Richard B Lomax and Carmel M. McNicholas and Marc Lomb{\`e}s and Geoffrey I. Sandle},
  journal={The American journal of physiology},
  year={1994},
  volume={266 1 Pt 1},
  pages={G71-82}
}
Aldosterone is a major regulator of Na(+)-absorptive and K(+)-secretory processes in the distal segment of mammalian colon. In this study, the distribution of aldosterone-sensitive cell types in isolated rat distal colon was determined using site-directed intracellular microelectrodes, specific Na(+)- and K(+)-channel blockers, and aldosterone-receptor binding techniques. Electrophysiological data indicated that aldosterone induced parallel apical membrane Na+ and K+ conductances, mainly in… CONTINUE READING