Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter.

@article{Grossmann2007AldosteroneinducedEE,
  title={Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter.},
  author={Claudia Grossmann and Alexander W. Krug and Ruth Freudinger and Sigrid Mildenberger and Katharina Voelker and Michael Gekle},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 6},
  pages={
          E1790-800
        }
}
  • C. GrossmannA. Krug M. Gekle
  • Published 1 June 2007
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
Aldosterone plays a key role in cardiovascular and renal injury. The underlying mechanisms are not completely understood. Because the epidermal growth factor receptor (EGFR) is involved in the development of fibrosis and vascular dysfunction, upregulation of EGFR expression by aldosterone-bound mineralocorticoid receptor (MR) is an attractive hypothesis. We investigated the effect of aldosterone on EGFR expression in the aorta of adrenalectomized rats and in human aorta smooth muscle cells… 
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...

52 References

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  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2003
The results provide the first evidence that the EGF receptor mediates at least two of the major actions of endothelin in the vascular tissue: contractility and fibrogenesis.

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...