Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs.

@article{Knights2009AldosteroneGB,
  title={Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs.},
  author={Kathleen M Knights and Leanne K Winner and David J. Elliot and Kushari Bowalgaha and John O. Miners},
  journal={British journal of clinical pharmacology},
  year={2009},
  volume={68 3},
  pages={402-12}
}
AIMS To characterize: i) the kinetics of aldosterone (ALDO) 18beta-glucuronidation using human liver and human kidney microsomes and identify the human UGT enzyme(s) responsible for ALDO 18beta-glucuronidation and ii) the inhibition of ALDO 18beta-glucuronidation by non-selective NSAIDs. METHODS Using HPLC and LC-MS methods, ALDO 18beta-glucuronidation… CONTINUE READING