Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.

@article{Cassis2005AldosteroneDN,
  title={Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.},
  author={Lisa A. Cassis and Marc J Helton and Deborah A. Howatt and Victoria L. King and Alan Daugherty},
  journal={British journal of pharmacology},
  year={2005},
  volume={144 3},
  pages={443-8}
}
We have demonstrated previously that infusion of angiotensin II (AngII) into hyperlipidemic mice augments atherosclerosis and results in the formation of abdominal aortic aneurysms (AAA). The purpose of this study was to determine the role of aldosterone in these AngII-induced vascular pathologies. Male apolipoprotein E-/- (apoE) mice were infused with either vehicle or aldosterone (50 or 200 ng kg(-1) min(-1)). Arterial blood pressure was determined throughout the study and serum lipid… CONTINUE READING