Aldosterone antagonists. 2. New 7 alpha-(acetylthio)-15,16-methylene spirolactones.

  title={Aldosterone antagonists. 2. New 7 alpha-(acetylthio)-15,16-methylene spirolactones.},
  author={K Nickisch and D Bittler and Henry Laurent and Wolfgang Losert and Jorge Casals-Stenzel and Yukishige Nishino and Eric F J Schillinger and R J Wiechert},
  journal={Journal of medicinal chemistry},
  volume={30 8},
Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone were synthesized with the purpose of increasing the antialdosterone potency and reducing the endocrinological effects of this standard compound. By introduction of a 1,2-double bond and a 15 beta,16 beta-methylene ring in the spironolactone molecule both goals were achieved. In… CONTINUE READING