Aldosterone and the conquest of land

@article{Colombo2006AldosteroneAT,
  title={Aldosterone and the conquest of land},
  author={L. Colombo and L. D. Valle and C. Fiore and D. Armanini and P. Belvedere},
  journal={Journal of Endocrinological Investigation},
  year={2006},
  volume={29},
  pages={373-379}
}
The sequence of the phylogenetic events that preceded the appearance of aldosterone in vertebrates is described, starting from the ancestral conversion of cytochrome P450s from oxygen detoxification to xenobiotic detoxification and synthesis of oxygenated endobiotics with useful functions in intercellular signalling, such as steroid hormones. At the end of the Silurian period [438–408 million yr ago, (Mya)], a complete set of cytochrome P450s for corticoid synthesis was presumably already… Expand
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