Aldosterone and renal injury.

@article{Nishiyama2004AldosteroneAR,
  title={Aldosterone and renal injury.},
  author={Akira Nishiyama and Youichi Abe},
  journal={Nihon yakurigaku zasshi. Folia pharmacologica Japonica},
  year={2004},
  volume={124 2},
  pages={
          101-9
        }
}
Our recent efforts have been focused on the mechanisms responsible for the progression of aldosterone-induced renal injury. We have demonstrated in rats that chronic treatment with aldosterone (0.75 micro g/H, SC) and 1% NaCl (in drinking solution) results in severe proteinuria and glomerular injury, characterized by cell proliferation and mesangial matrix expansion. Increased renal cortical NAD(P)H oxidase expression, reactive oxygen species (ROS) generation, and mitogen-activated protein… CONTINUE READING
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Aldosterone promotes proximal tubular cell apoptosis: role of oxidative stress.

  • American journal of physiology. Renal physiology
  • 2007
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