Aldosterone and myocardial extracellular matrix expansion in type 2 diabetes mellitus.

@article{Rao2013AldosteroneAM,
  title={Aldosterone and myocardial extracellular matrix expansion in type 2 diabetes mellitus.},
  author={Ajay Rao and Ravi Vikram Shah and Rajesh Garg and Siddique A Abbasi and Tomas G. Neilan and Todd S. Perlstein and Marcelo Di Carli and Michael Jerosch-Herold and Raymond Y. Kwong and Gail K. Adler},
  journal={The American journal of cardiology},
  year={2013},
  volume={112 1},
  pages={73-8}
}
Myocardial extracellular matrix expansion and reduced coronary flow reserve (CFR) occur in patients with type 2 diabetes mellitus without heart failure or coronary artery disease. Because aldosterone is implicated in the pathophysiology of cardiac fibrosis and vascular injury, the aim of this study was to test the hypothesis that aldosterone is associated with extracellular matrix expansion and reduced CFR in type 2 diabetes mellitus. Patients with type 2 diabetes mellitus without evidence of… CONTINUE READING

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