Aldosterone and TGF-β₁ synergistically increase PAI-1 expression in hepatic stellate cells of rats.

@article{Wang2015AldosteroneAT,
  title={Aldosterone and TGF-β₁ synergistically increase PAI-1 expression in hepatic stellate cells of rats.},
  author={Sheng-Lan Wang and Hui-min Wu and Cheng-Zhi He and Li Yang and Heng-jun Gao and Chang-Qing Yang},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 9},
  pages={
          9845-53
        }
}
OBJECTIVE Aldosterone is related to the fibrosis of several organs, but the specific mechanism underlying the aldosterone induced hepatic fibrosis is still unclear. METHODS Separation, culture and identification of primary hepatic stellate cells (HSCs): The fluids and digestives used in the present study were able to completely remove blood cells, digest hepatocytes and matrix, and effectively separate HSCs. The in situ perfusion was performed at 2 steps: in situ perfusion with pre-perfusion… CONTINUE READING

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