Aldosterone activates Na+/H+ exchange in vascular smooth muscle cells by nongenomic and genomic mechanisms.

@article{Ebata1999AldosteroneAN,
  title={Aldosterone activates Na+/H+ exchange in vascular smooth muscle cells by nongenomic and genomic mechanisms.},
  author={Shigeo Ebata and Shigeaki Muto and Koji Okada and Joe Nemoto and Morimasa Amemiya and Takako Saito and Yasushi Asano},
  journal={Kidney international},
  year={1999},
  volume={56 4},
  pages={1400-12}
}
BACKGROUND In vascular smooth muscle cells (VSMCs), Na+/H+ exchange (NHE) plays an important role in intracellular pH (pHi) regulation. Recently, nongenomic effect of aldosterone (ALDO) on NHE activity has been suggested in VSMCs. However, the nongenomic and genomic effects of ALDO on NHE and the intracellular signaling mechanisms for these effects have not fully been determined in VSMCs. METHODS The effects of short- (3 hr) and long- (24 hr) term exposure to ALDO on NHE activity were… CONTINUE READING
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