Aldosterone activates Na+/H+ exchange and raises cytoplasmic pH in target cells of the amphibian kidney.

@article{Oberleithner1987AldosteroneAN,
  title={Aldosterone activates Na+/H+ exchange and raises cytoplasmic pH in target cells of the amphibian kidney.},
  author={Hans Oberleithner and Mareile Weigt and H J Westphale and Weiru Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 5},
  pages={1464-8}
}
The hypothesis was tested if the mineralocorticoid hormone aldosterone stimulates Na+/H+ exchange in "giant cells" fused from individual target cells of the distal nephron of the frog kidney. By means of microelectrodes, steady-state intracellular pH (pHi) and pHi recovery from an acid load were recorded continuously while the fused cells were exposed to aldosterone. Twenty minutes after addition of the hormone, pHi started to rise and reached a new steady state after about 60 min (delta pHi… CONTINUE READING

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