Aldosterone Increases Early Atherosclerosis and Promotes Plaque Inflammation Through a Placental Growth Factor‐Dependent Mechanism

@inproceedings{Mcgraw2013AldosteroneIE,
  title={Aldosterone Increases Early Atherosclerosis and Promotes Plaque Inflammation Through a Placental Growth Factor‐Dependent Mechanism},
  author={Adam Mcgraw and Jessamyn Bagley and Wei‐Sheng Chen and Carol Galayda and Heather Nickerson and Andrea Armani and Massimiliano Caprio and Peter Carmeliet and Iris Z Jaffe},
  booktitle={Journal of the American Heart Association},
  year={2013}
}
BACKGROUND Aldosterone levels correlate with the incidence of myocardial infarction and mortality in cardiovascular patients. Aldosterone promotes atherosclerosis in animal models, but the mechanisms are poorly understood. METHODS AND RESULTS Aldosterone was infused to achieve pathologically relevant levels that did not increase blood pressure in the atherosclerosis-prone apolipoprotein E-knockout mouse (ApoE-/-). Aldosterone increased atherosclerosis in the aortic root 1.8±0.1-fold after 4… CONTINUE READING
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