• DOI:10.1007/s10741-005-2343-3
Corpus ID: 19588366

Aldosterone Biosynthesis, Regulation, and Classical Mechanism of Action

@article{Williams2005AldosteroneBR,
  title={Aldosterone Biosynthesis, Regulation, and Classical Mechanism of Action},
  author={G. Williams},
  journal={Heart Failure Reviews},
  year={2005},
  volume={10},
  pages={7-13}
}

G. Williams

Published 2005

Medicine

Heart Failure Reviews

Circulating aldosterone is principally made in the glomerulosa zone of the adrenal cortex by a series of enzyme steps leading to the conversion of cholesterol to aldosterone. Uniquely, aldosterone’s production is regulated at two critical enzyme steps: (1) early in its biosynthetic pathway (the conversion of cholesterol to pregnenolone cholesterol side chain cleavage enzyme) and (2) late (the conversion of corticosterone to aldosterone by aldosterone synthase). A variety of factors modify… CONTINUE READING

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