Aldosterone Biosynthesis, Regulation, and Classical Mechanism of Action

  title={Aldosterone Biosynthesis, Regulation, and Classical Mechanism of Action},
  author={G. Williams},
  journal={Heart Failure Reviews},
  • G. Williams
  • Published 2005
  • Medicine
  • Heart Failure Reviews
  • Circulating aldosterone is principally made in the glomerulosa zone of the adrenal cortex by a series of enzyme steps leading to the conversion of cholesterol to aldosterone. Uniquely, aldosterone’s production is regulated at two critical enzyme steps: (1) early in its biosynthetic pathway (the conversion of cholesterol to pregnenolone cholesterol side chain cleavage enzyme) and (2) late (the conversion of corticosterone to aldosterone by aldosterone synthase). A variety of factors modify… CONTINUE READING
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