Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells.

@article{Ramana2002AldoseRM,
  title={Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells.},
  author={Kota V Ramana and Deepak Chandra and Sanjay Kumar Srivastava and Aruni Bhatnagar and Bharat Bhushan Aggarwal and Satish K. Srivastava},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 35},
  pages={32063-70}
}
Abnormal vascular smooth muscle cell (VSMC) proliferation is a key feature of atherosclerosis and restenosis; however, the mechanisms regulating growth remain unclear. Herein we show that inhibition of the aldehyde-metabolizing enzyme aldose reductase (AR) inhibits NF-kappa B activation during restenosis of balloon-injured rat carotid arteries as well as VSMC proliferation due to tumor necrosis factor alpha (TNF-alpha) stimulation. Inhibition of VSMC growth by AR inhibitors was not accompanied… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Immunodetection of aldose reductase in normal and diseased human liver.

Histology and histopathology • 2005
View 5 Excerpts
Highly Influenced

Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy.

American journal of physiology. Heart and circulatory physiology • 2011
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-2 of 2 references

1007-1013 by gest on Sptem er 1, 2017 hp://w w w .jb.org/ D

H. L. Rittner, V. Hafner, +3 authors C. M. Weyand
J. Clin. Invest • 1999
View 3 Excerpts
Highly Influenced

8604-8609 by gest on Sptem er 1, 2017 hp://w w w .jb.org/ D

P. J. Donohue, G. F. Alberts, B. S. Hampton, J. A. Winkles
J. Biol. Chem • 1994
View 1 Excerpt

Similar Papers

Loading similar papers…