Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.

@article{Obrosova2003AldoseRI,
  title={Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats.},
  author={Irina G. Obrosova and Alexander G. Minchenko and Rukmini Vasupuram and Lorraine White and Omorodola I Abatan and Arno K. Kumagai and Robert N. Frank and Martin J. Stevens},
  journal={Diabetes},
  year={2003},
  volume={52 3},
  pages={
          864-71
        }
}
The study addressed the role for aldose reductase (AR) in 1) retinal oxidative stress and vascular endothelial growth factor (VEGF) overexpression in early diabetes, and 2) high glucose-induced oxidative stress in retinal endothelial cells. In vivo experiments were performed on control rats and diabetic rats treated with or without low or high dose of the AR inhibitor (ARI) fidarestat (2 or 16 mg. kg(-1). day(-1)). In vitro studies were performed on bovine retinal endothelial cells (BREC… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 56 references

An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2002
View 5 Excerpts
Highly Influenced

How does glucose generate oxidative stress in peripheral nerve?

International review of neurobiology • 2002
View 6 Excerpts
Highly Influenced

Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity.

American journal of physiology. Cell physiology • 2002
View 3 Excerpts
Highly Influenced

: protection by allopurinol

MF Lou, JE Dickerson, R Garadi, BM York
2002

Hyperglycemiainduced superoxide activates PKC, the hexosamine poathway, AGE formation, and NF B via poly(ADP-ribose)polymerase inhibition of GAPDH (Abstract)

X Du, T Matsumura, C Szabó, D Edelstein, M Brownlee
Diabetes 51 (Suppl • 2002
View 1 Excerpt

Poly(ADP-ribose)synthetase inhibitors counteract diabetes- and hypoxiainduced retinal VEGF formation (Abstract)

I Obrosova, A Minchenko, +3 authors M Stevens
Ophthalm Res • 2002
View 1 Excerpt