Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors.

Abstract

One of the major problems associated with the chemotherapy of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) that selectively kills tumor cells is decreased drug resistance. This warranted the development of safe novel pharmacological agents that could sensitize the tumor cells to TRAIL. Herein, we examined the role of aldose… (More)
DOI: 10.1016/j.freeradbiomed.2013.05.039

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@article{Shoeb2013AldoseRI, title={Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO3a-dependent upregulation of death receptors.}, author={Mohammad Shoeb and K. Venkat Ramana and Satish K. Srivastava}, journal={Free radical biology & medicine}, year={2013}, volume={63}, pages={280-90} }