Aldose reductase inhibition alone or combined with an adenosine A(3) agonist reduces ischemic myocardial injury.

@article{Tracey2000AldoseRI,
  title={Aldose reductase inhibition alone or combined with an adenosine A(3) agonist reduces ischemic myocardial injury.},
  author={W. Ross Tracey and William P Magee and Craig A Ellery and J T MacAndrew and Andrew Henry Smith and Delvin R. Knight and Peter J. Oates},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 4},
  pages={H1447-52}
}
This study investigated whether aldose reductase (AR) inhibition with zopolrestat, either alone or in combination with an adenosine A(3)-receptor agonist (CB-MECA), reduced myocardial ischemic injury in rabbit hearts subjected to 30 min of regional ischemia and 120 min of reperfusion. Zopolrestat reduced infarct size by up to 61%, both in vitro (2 nM to 1 microM; EC(50) = 24 nM) and in vivo (50 mg/kg). Zopolrestat reduced myocardial sorbitol concentration (index of AR activity) by >50% (control… CONTINUE READING