Aldose reductase induction: a novel response to oxidative stress of smooth muscle cells.

@article{Spycher1997AldoseRI,
  title={Aldose reductase induction: a novel response to oxidative stress of smooth muscle cells.},
  author={S E Spycher and Shirin Tabataba-Vakili and Valerie B O'Donnell and Letizia Palomba and Angelo Azzi},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1997},
  volume={11 2},
  pages={
          181-8
        }
}
Hydrogen peroxide (H2O2) or 4-hydroxy-2,3-trans-nonenal (HNE) treatment of rat vascular smooth muscle cells (A7r5) caused induction of aldose reductase mRNA. Induction was dose (10-100 microM H2O2, 1-10 microM HNE) and time dependent, reaching a maximum (three- to fourfold) after 7-12 h. Treatment of cells with actinomycin D confirmed de novo synthesis of aldose reductase mRNA. H2O2-induced expression was prevented by catalase but unaffected by Desferal, indicating that metal catalyzed… CONTINUE READING
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