Aldose reductase-deficient mice develop nephrogenic diabetes insipidus.

  title={Aldose reductase-deficient mice develop nephrogenic diabetes insipidus.},
  author={H T B Ho and Sookja Kim Chung and Janice W. S. Law and Ben Chi Bun Ko and Siu Cheung Tam and Heddwen L. Brooks and Mark A. Knepper and Stephen S M Chung},
  journal={Molecular and cellular biology},
  volume={20 16},
Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive… CONTINUE READING