Aldose reductase: a key player in myocardial ischemic injury.

@article{Kaneko2004AldoseRA,
  title={Aldose reductase: a key player in myocardial ischemic injury.},
  author={Michiyo Kaneko and Ravichandran Ramasamy},
  journal={Exercise and sport sciences reviews},
  year={2004},
  volume={32 1},
  pages={19-23}
}
In the search for increasing effectiveness of reperfusion therapy, the authors demonstrate that the polyol pathway enzyme aldose reductase is a key component of myocardial ischemic injury and that inhibitors of this enzyme limit ischemic injury and improve functional recovery on reperfusion.