Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites.

@article{Jewett2003AldolaseFA,
  title={Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites.},
  author={Travis J. Jewett and L. David Sibley},
  journal={Molecular cell},
  year={2003},
  volume={11 4},
  pages={885-94}
}
Host cell invasion by apicomplexan parasites requires coordinated interactions between cell surface adhesins and the parasite cytoskeleton. We have identified a complex of parasite proteins, including the actin binding protein aldolase, which specifically interacts with the C-terminal domains of several parasite adhesins belonging to the thrombospondin-related anonymous protein (TRAP) family. Binding of aldolase to the adhesin was disrupted by mutation of a critical tryptophan in the C domain… CONTINUE READING
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