Aldo-keto reductase from Helicobacter pylori--role in adaptation to growth at acid pH.

@article{Cornally2008AldoketoRF,
  title={Aldo-keto reductase from Helicobacter pylori--role in adaptation to growth at acid pH.},
  author={Denise Cornally and Blanaid Mee and Ciar{\'a}n MacDonaill and Keith F. Tipton and D. Matthew Kelleher and Henry J. Windle and Gary T. M. Henehan},
  journal={The FEBS journal},
  year={2008},
  volume={275 12},
  pages={
          3041-50
        }
}
Pyridine-linked oxidoreductase enzymes of Helicobacter pylori have been implicated in the pathogenesis of gastric disease. Previous studies in this laboratory examined a cinnamyl alcohol dehydrogenase that was capable of detoxifying a range of aromatic aldehydes. In the present work, we have extended these studies to identify and characterize an aldoketo reductase (AKR) enzyme present in H. pylori. The gene encoding this AKR was identified in the sequenced strain of H. pylori, 26695. The gene… CONTINUE READING
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