Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma.

@article{Miller2012AldoketoRF,
  title={Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma.},
  author={Valerie L Miller and Hsueh-Kung Lin and Paari Murugan and Michael Dahua Fan and Trevor M Penning and Lacy S Brame and Qing Yang and K M Fung},
  journal={International journal of clinical and experimental pathology},
  year={2012},
  volume={5 4},
  pages={278-89}
}
Human aldo-keto reductase family 1 member C3 (AKR1C3) was initially identified as a critical enzyme in reducing 5α-dihydrotestosterone (5α-DHT) to 5α-androstane-3α,17β-diol (3α-diol) and oxidizing 3α-diol to androsterone. Based on these enzymatic activities, AKR1C3 was originally named type 2 3α-hydroxysteroid dehydrogenase (HSD)/type 5 17β-HSD. Additionally, AKR1C3 was demonstrated to be capable of metabolizing other steroids including estrogen and progesterone. Subsequently, AKR1C3 was shown… CONTINUE READING
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