Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates.

@article{Weber2015AldoketoR1,
  title={Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates.},
  author={Susanne Weber and Joshua K. Salabei and Gabriele Moeller and Elisabeth Kremmer and Aruni Bhatnagar and Jerzy Adamski and Oleg A. Barski},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 10},
  pages={6531-45}
}
Aldo-keto reductases (AKRs) comprise a superfamily of proteins involved in the reduction and oxidation of biogenic and xenobiotic carbonyls. In humans, at least 15 AKR superfamily members have been identified so far. One of these is a newly identified gene locus, AKR1B15, which clusters on chromosome 7 with the other human AKR1B subfamily members (i.e. AKR1B1 and AKR1B10). We show that alternative splicing of the AKR1B15 gene transcript gives rise to two protein isoforms with different N… CONTINUE READING