Aldo–Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers

@inproceedings{Matsunaga2012AldoKetoR1,
  title={Aldo–Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers},
  author={Toshiyuki Matsunaga and Yasuhiro Wada and Satoshi Endo and Midori Soda and Ossama El-Kabbani and Akira Hara},
  booktitle={Front. Pharmacol.},
  year={2012}
}
The human aldo-keto reductase AKR1B10, originally identified as an aldose reductase-like protein and human small intestine aldose reductase, is a cytosolic NADPH-dependent reductase that metabolizes a variety of endogenous compounds, such as aromatic and aliphatic aldehydes and dicarbonyl compounds, and some drug ketones. The enzyme is highly expressed in solid tumors of several tissues including lung and liver, and as such has received considerable interest as a relevant biomarker for the… CONTINUE READING

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