Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds

  title={Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds},
  author={Haining Wang and Xi-Jie Dai and Chao‐Jun Li},
  journal={Nature Chemistry},
  pages={374 - 378}
Nucleophilic addition reactions of organometallic reagents to carbonyl compounds for carbon–carbon bond construction have played a pivotal role in modern chemistry. However, this reaction's reliance on petroleum-derived chemical feedstocks and a stoichiometric quantity of metal have prompted the development of many carbanion equivalents and catalytic metal alternatives. Here, we show that naturally occurring carbonyls can be used as latent alkyl carbanion equivalents for additions to carbonyl… 

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