Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development.


High levels of the aldehyde dehydrogenase isoform ALDH1A1 are expressed in hematopoietic stem cells (HSCs); however, its importance in these cells remains unclear. Consistent with an earlier report, we find that loss of ALDH1A1 does not affect HSCs. Intriguingly, however, we find that ALDH1A1 deficiency is associated with increased expression of the ALDH3A1… (More)
DOI: 10.1016/j.exphem.2011.12.006


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