• DOI:10.1016/J.EJMECH.2007.06.004
Corpus ID: 27841619

Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture.

@article{Quash2008AldehydeDI,
  title={Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture.},
  author={G. Quash and G. Fournet and Charlotte Courvoisier and R. M. Mart{\'i}nez and J. Chantepie and M. J. Paret and J. Pharaboz and Marie Odile Joly-Pharaboz and J. Gore and J. Andr{\'e} and U. Reichert},
  journal={European journal of medicinal chemistry},
  year={2008},
  volume={43 5},
  pages={
          906-16
        }
}

G. Quash, G. Fournet, +8 authors U. Reichert

Published 2008

Chemistry, Medicine

European journal of medicinal chemistry

The pharmacomodulation of the N atom of alpha,beta-acetylenic aminothiolesters or the replacement of the thiolester moiety by more electrophilic groups did not permit any clear rationale to be established for improving the selective growth-inhibitory activity of this family of compounds over that of the previously synthesized alpha,beta-acetylenic aminothiolesters DIMATE and MATE [G. Quash, G. Fournet, J. Chantepie, J. Goré, C. Ardiet, D. Ardail, Y. Michal, U. Reichert, Biochem Pharmacol 64… CONTINUE READING

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