Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion

Abstract

Among ALDH isoforms, ALDH1L1 in the folate pathway showed highly increased expression in non-small-cell lung cancer cells (NSCLC). Based on the basic mechanism of ALDH converting aldehyde to carboxylic acid with by-product NADH, we suggested that ALDH1L1 may contribute to ATP production using NADH through oxidative phosphorylation. ALDH1L1 knockdown reduced… (More)
DOI: 10.18632/oncotarget.10354

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