Aldehyde dehydrogenase genotypes In Japanese alcoholics

  title={Aldehyde dehydrogenase genotypes In Japanese alcoholics},
  author={Susumu Higuchi and Sachio Matsushita and Hiromi Imazeki and Tadao Kinoshita and Satoshi Takagi and Hiroaki Kono},
  journal={The Lancet},

Mendelian randomization: A novel test of the gateway hypothesis and models of gene–environment interplay

It was found that ALDH2 deficiency was significantly associated with lower rates of drinking and getting drunk but not with ever having tried alcohol, and siblings rather than parents was identified as the major source of familial environmental effect on adolescent drinking.

Gene-environment interplay and psychopathology: multiple varieties but real effects.

This review of research evidence on four varieties of gene-environment interplay considers epigenetic mechanisms by which environmental influences alter the effects of genes and focuses on variations in heritability according to environmental circumstances.

Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology

The strongest correlations found to date have been those between the ALDH2*2 allele and cancers of the oro-pharynx and oesophagus, and it will be important to replicate other interesting associations between these variants and other cancers and heart disease, and to determine the biochemical mechanisms underlying the associations.

Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.

It is suggested that protection afforded by the ADH2*2 allele may be independent of that afforded by ALDH2* 2, and that individuals carrying one or two copies of ADH 2 and a single copy of ALDH 2*2 had the lowest risk for alcoholism, as compared with the ADh2*1/*1 and ALDH1*1 genotype.

An experimental analysis of acquired impulse control among adult humans intolerant to alcohol

It is found that alcohol intolerance, which occurs randomly and leads affected people systematically to resist the impulse to consume alcohol, enables improved impulse control in another behavioral domain and indicates that impulse control can be developed in adult populations as a result of self-control behaviors in natural environments.

Asian Flushing: Genetic and Sociocultural Factors of Alcoholism Among East Asians

  • Haeok LeeSun S. Kim L. Hayman
  • Medicine
    Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates
  • 2014
The purpose of this article was to provide nurses with the most current information about genetic and sociocultural influences on alcoholism and alcohol-related health problems specifically for East Asians and implications of this knowledge to nursing practice.

Disentangling the relationships between maternal smoking during pregnancy and co-occurring risk factors

The intergenerational transmission of genes conferring risk for antisocial behavior and substance misuse may influence the associations between maternal SDP and adverse offspring outcomes.

Difference between urban and rural regions in Japan in estimated risk of esophageal cancer based on a health risk appraisal model that includes an alcohol flushing questionnaire

The risk of ESCC quantitatively assessed based on the HRA-F scores was higher in Oita men than in Tokyo men, but a higher proportion of women were at high risk in Tokyo than in O Vita, Japan.

Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians

Results support a strong association of alcohol abuse and dependence and provide confirmation of the involvement of the human ALDH2 gene in the pathogenesis of AD as well as alcohol-induced medical illnesses in East-Asians.

Subjective Responses to Alcohol Consumption as Endophenotypes: Advancing Behavioral Genetics in Etiological and Treatment Models of Alcoholism

A critical review of the literature on subjective response to alcohol and the rationale for its conceptualization as an endophenotype for alcoholism is discussed, and a framework for conceptualizing, and systematically integrating, endophenotypes into alcoholism treatment is proposed.



Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.

The polymerase chain reaction is used to determine the genotypes of 24 livers from Japanese individuals and it is concluded that the allele (ALDH2(2)) encoding the abnormal subunit is dominant.