Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide.

@article{Kanakry2013AldehydeDE,
  title={Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide.},
  author={Christopher G. Kanakry and S Ganguly and Marianna Zahurak and Javier Bola{\~n}os-Meade and Christopher Thoburn and Brandy N. Perkins and Ephraim Joseph Fuchs and Richard M. Jones and AllanD. Hess and Leo Luznik},
  journal={Science translational medicine},
  year={2013},
  volume={5 211},
  pages={
          211ra157
        }
}
High-dose, posttransplantation cyclophosphamide (PTCy) is an effective strategy for preventing graft-versus-host disease (GVHD) after allogeneic blood or marrow transplantation (alloBMT). However, the mechanisms by which PTCy modulates alloimmune responses are not well understood. We studied early T cell reconstitution in patients undergoing alloBMT with PTCy and the effects of mafosfamide, a cyclophosphamide (Cy) analog, on CD4(+) T cells in allogeneic mixed lymphocyte reactions (MLRs) in… CONTINUE READING
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