Aldehyde dehydrogenase activity selects for the holoclone phenotype in prostate cancer cells.

@article{Doherty2011AldehydeDA,
  title={Aldehyde dehydrogenase activity selects for the holoclone phenotype in prostate cancer cells.},
  author={Rachel E Doherty and S L Haywood-Small and Karen Sisley and Neil Alan Cross},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={414 4},
  pages={801-7}
}
Aldehyde dehydrogenase 1 (ALDH) activity is considered to be a marker of cancer stem cells (CSCs) in many tumour models, since these cells are more proliferative and tumourigenic than ALDH(Lo) cells in experimental models. However it is unclear whether all CSC-like cells are within the ALDH(Hi) population, or whether all ALDH(Hi) cells are highly proliferative and tumourigenic. The ability to establish a stem cell hierarchy in vitro, whereby sub-populations of cells have differing proliferative… CONTINUE READING

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