Aldehyde dehydrogenase activity promotes survival of human muscle precursor cells

  title={Aldehyde dehydrogenase activity promotes survival of human muscle precursor cells},
  author={Elise Jean and Dalila Laoudj-Chenivesse and C{\'e}cile Notarnicola and Karl Rouger and Nicolas Serratrice and Anne Bonnieu and St{\'e}phanie Gay and Francis Bacou and C{\'e}dric Duret and Gilles Carnac},
  booktitle={Journal of cellular and molecular medicine},
Aldehyde dehydrogenases (ALDH) are a family of enzymes that efficiently detoxify aldehydic products generated by reactive oxygen species and might therefore participate in cell survival. Because ALDH activity has been used to identify normal and malignant cells with stem cell properties, we asked whether human myogenic precursor cells (myoblasts) could be identified and isolated based on their levels of ALDH activity. Human muscle explant-derived cells were incubated with ALDEFLUOR, a… CONTINUE READING


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