Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans.

Abstract

OBJECTIVE Nitrates are used widely in clinical practice. However, the mechanism underlying the bioactivation of nitrates to release NO remains unclear. Recent animal data suggest that mitochondrial aldehyde dehydrogenase (ALDH2) plays a central role in nitrate bioactivation, but its role in humans is not known. We investigated the role of ALDH2 in the… (More)

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