Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?

  title={Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?},
  author={Grant R. Budas and M H Disatnik and Daria Mochly-Rosen},
  journal={Trends in cardiovascular medicine},
  volume={19 5},
Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is emerging as a key enzyme involved in cytoprotection in the heart. ALDH2 mediates both the detoxification of reactive aldehydes such as acetaldehyde and 4-hydroxy-2-nonenal and the bioactivation of nitroglycerin to nitric oxide. In addition, chronic nitrate treatment results in ALDH2 inhibition and contributes to nitrate tolerance. Our laboratory recently identified ALDH2 to be a key mediator of endogenous cytoprotection. We reported that ALDH2… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 50 extracted citations


Publications referenced by this paper.
Showing 1-10 of 59 references

Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans.

Arteriosclerosis, thrombosis, and vascular biology • 2005
View 10 Excerpts
Highly Influenced

Reactions of 4-hydroxynonenal with proteins and cellular targets.

Free radical biology & medicine • 2004
View 4 Excerpts
Highly Influenced

Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase.

Trends in cardiovascular medicine • 2006
View 4 Excerpts
Highly Influenced

4-hydroxynonenal inhibits Na(+)-K(+)-ATPase.

Free radical biology & medicine • 1996
View 3 Excerpts
Highly Influenced

Male-female differences in post translational modifications of mitochondrial proteins

CJ Lagranha, C Steenbergen, E Murphy
FASEB J 23:508.1 • 2009
View 3 Excerpts

Similar Papers

Loading similar papers…