Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice.

@article{Kwon2014AldehydeD2,
  title={Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice.},
  author={Hyo-Jung Kwon and Young-Suk Won and Ogyi Park and Binxia Chang and Michael J Duryee and Geoffrey E Thiele and Akiko Matsumoto and Surendra Singh and Mohamed A Abdelmegeed and B J Song and Toshihiro Kawamoto and Vasilis Vasiliou and Geoffrey M Thiele and Bin Gao},
  journal={Hepatology},
  year={2014},
  volume={60 1},
  pages={
          146-57
        }
}
UNLABELLED Aldehyde dehydrogenase 2 (ALDH2) is the major enzyme that metabolizes acetaldehyde produced from alcohol metabolism. Approximately 40-50% of East Asians carry an inactive ALDH2 gene and exhibit acetaldehyde accumulation after alcohol consumption. However, the role of ALDH2 deficiency in the pathogenesis of alcoholic liver injury remains obscure. In the present study, wild-type and ALDH2(-/-) mice were subjected to ethanol feeding and/or carbon tetrachloride (CCl4 ) treatment, and… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…