Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice

@article{Kwon2014AldehydeD2,
  title={Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice},
  author={Hyo-Jung Kwon and Young-Suk Won and O. Park and B. Chang and M. Duryee and Geoffrey E Thiele and A. Matsumoto and S. Singh and M. Abdelmegeed and Byoung-Joon Song and T. Kawamoto and V. Vasiliou and G. Thiele and B. Gao},
  journal={Hepatology},
  year={2014},
  volume={60}
}
  • Hyo-Jung Kwon, Young-Suk Won, +11 authors B. Gao
  • Published 2014
  • Medicine, Biology
  • Hepatology
  • Aldehyde dehydrogenase 2 (ALDH2) is the major enzyme that metabolizes acetaldehyde produced from alcohol metabolism. Approximately 40‐50% of East Asians carry an inactive ALDH2 gene and exhibit acetaldehyde accumulation after alcohol consumption. However, the role of ALDH2 deficiency in the pathogenesis of alcoholic liver injury remains obscure. In the present study, wild‐type and ALDH2−/− mice were subjected to ethanol feeding and/or carbon tetrachloride (CCl4) treatment, and liver injury was… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 42 REFERENCES
    Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice
    20
    Hepatic‐specific lipin‐1 deficiency exacerbates experimental alcohol‐induced steatohepatitis in mice
    46
    Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
    114
    Acetaldehyde adducts in alcoholic liver disease.
    167
    Ethanol‐Induced Oxidative DNA Damage and CYP2E1 Expression in Liver Tissue of Aldh2 Knockout Mice
    25
    Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes.
    241