Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.

@article{Gomes2014AldehydeD2,
  title={Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.},
  author={K{\'a}tia Maria Sampaio Gomes and Juliane Cruz Campos and Luiz Roberto Grassmann Bechara and Bruno B Queliconi and Vanessa Morais Lima and M H Disatnik and Paulo Magno and Che-Hong Chen and Patr{\'i}cia C Brum and Alicia J Kowaltowski and Daria Mochly-Rosen and Julio C B Ferreira},
  journal={Cardiovascular research},
  year={2014},
  volume={103 4},
  pages={498-508}
}
AIMS We previously demonstrated that pharmacological activation of mitochondrial aldehyde dehydrogenase 2 (ALDH2) protects the heart against acute ischaemia/reperfusion injury. Here, we determined the benefits of chronic activation of ALDH2 on the progression of heart failure (HF) using a post-myocardial infarction model. METHODS AND RESULTS We showed that a 6-week treatment of myocardial infarction-induced HF rats with a selective ALDH2 activator (Alda-1), starting 4 weeks after myocardial… CONTINUE READING
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Mitochondria as a therapeutic target in heart failure.

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