Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer

@article{Matsumoto2017AldehydeD1,
  title={Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer},
  author={Akiko Matsumoto and John J. Arcaroli and Yin Chen and Maura Gasparetto and Veronique M. Neumeister and David C. Thompson and Surendra Singh and Clayton Smith and Wells A. Messersmith and Vasilis Vasiliou},
  journal={British Journal of Cancer},
  year={2017},
  volume={117},
  pages={1537-1543}
}
Background:Aldehyde dehydrogenase (ALDH) 1A1 is an immunohistological biomarker of various solid tumours, but has not been successfully proved as a colorectal cancer (CRC) marker. We recently reported that ALDH1B1, which has functional roles in tumourigenesis, may be a better CRC marker than ALDH1A1.Methods:Human CRC explants and cell lines were analysed to identify candidate CRC markers from eight ALDH isozymes including ALDH1A1 and ALDH1B1. A tissue microarray, including paired specimens of… CONTINUE READING
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