Aldehyde dehydrogenase (ALDH) in Alzheimer’s and Parkinson’s disease

@article{Grnblatt2014AldehydeD,
  title={Aldehyde dehydrogenase (ALDH) in Alzheimer’s and Parkinson’s disease},
  author={Edna Gr{\"u}nblatt and Peter Franz Riederer},
  journal={Journal of Neural Transmission},
  year={2014},
  volume={123},
  pages={83-90}
}
Evidence suggests that aldehyde dehydrogenase (ALDH; E.C. 1.2.1.3) gene, protein expression and activity are substantially decreased in the substantia nigra of patients with Parkinson’s disease (PD). This holds especially true for cytosolic ALDH1A1, while mitochondrial ALDH2 is increased in the putamen of PD. Similarly, in Alzheimer’s disease (AD) several studies in genetic, transcriptomic, protein and animal models suggest ALDH involvement in the neurodegeneration processes. Such data are in… CONTINUE READING
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