Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse.

@article{Kitagawa2000AldehydeD,
  title={Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse.},
  author={Katsumi Kitagawa and Tomohiro Kawamoto and Naoki Kunugita and Takuji Tsukiyama and Kouichirou Okamoto and Akira Yoshida and Kazuhisa Nakayama},
  journal={FEBS letters},
  year={2000},
  volume={476 3},
  pages={
          306-11
        }
}
A principal pathway of 2-methoxyethanol (ME) metabolism is to the toxic oxidative product, methoxyacetaldehyde (MALD). To assess the role of aldehyde dehydrogenase (ALDH) in MALD metabolism, in vitro MALD oxidation was examined with liver subcellular fractions from Japanese subjects who carried three different ALDH2 genotypes and Aldh2 knockout mice, which were generated in this study. The activity was distributed in mitochondrial fractions of ALDH2*1/*1 and wild type (Aldh2+/+) mice but not… CONTINUE READING
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