Aldehyde Dehydrogenase1 Immunohistochemical Staining in Primary Breast Cancer Cells Independently Predicted Overall Survival But Did Not Correlate with the Presence of Circulating or Disseminated Tumors Cells

@inproceedings{Woodward2014AldehydeDI,
  title={Aldehyde Dehydrogenase1 Immunohistochemical Staining in Primary Breast Cancer Cells Independently Predicted Overall Survival But Did Not Correlate with the Presence of Circulating or Disseminated Tumors Cells},
  author={Wendy A Woodward and Savitri Krishnamurthy and Ashutosh K. Lodhi and Lianchun Xiao and Yun Guo Gong and Massimo Cristofanilli and Thomas A. Buchholz and Anthony J. Lucci},
  booktitle={Journal of Cancer},
  year={2014}
}
PURPOSE We hypothesized that aldehyde dehydrogenase 1 (ALDH1) staining in breast cancer tumor cells might be a simple surrogate for the presence of circulating tumor cells (CTCs) or disseminated tumor cells (DTCs). EXPERIMENTAL DESIGN Whole tissue primary tumor sections from 121 patients enrolled in a clinical trial assessing CTCs and DTCs at the time of surgery were stained for ALDH1 and scored by a dedicated breast pathologist blinded to outcome. Clinical data was extracted and staining was… CONTINUE READING