Aldehyde Dehydrogenase 1A1: Friend or Foe to Female Metabolism?

@inproceedings{Petrosino2014AldehydeD1,
  title={Aldehyde Dehydrogenase 1A1: Friend or Foe to Female Metabolism?},
  author={J. M. Petrosino and David Disilvestro and Ouliana Ziouzenkova},
  booktitle={Nutrients},
  year={2014}
}
In this review, we summarize recent advances in understanding vitamin A-dependent regulation of sex-specific differences in metabolic diseases, inflammation, and certain cancers. We focus on the characterization of the aldehyde dehydrogenase-1 family of enzymes (ALDH1A1, ALDH1A2, ALDH1A3) that catalyze conversion of retinaldehyde to retinoic acid. Additionally, we propose a "horizontal transfer of signaling" from estrogen to retinoids through the action of ALDH1A1. Although estrogen does not… CONTINUE READING
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