Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia.

@article{Covarrubias1995AlcoholsIA,
  title={Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia.},
  author={Manuel Covarrubias and T B Vyas and Laura Escobar and Aguan D. Wei},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 33},
  pages={19408-16}
}
The molecular basis of general anesthetic action on membrane proteins that control ion transport is not yet understood. In a previous report (Covarrubias, M., and Rubin, E. (1993) Proc. Natl. Acad. Sci. 90, 6957-6960), we found that low concentrations of ethanol (17-170mM) selectively inhibited a noninactivating cloned K+ channel encoded by Drosophila Shaw2. Here, we have conducted equilibrium dos-inhibition experiments, single channel recording, and mutagenesis in vitro to study the mechanism… CONTINUE READING
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