Alcohols induce beta-hematin formation via the dissociation of aggregated heme and reduction in interfacial tension of the solution.

@article{Huy2007AlcoholsIB,
  title={Alcohols induce beta-hematin formation via the dissociation of aggregated heme and reduction in interfacial tension of the solution.},
  author={Nguyen Tien Huy and Atsushi Maeda and Dinh Thanh Uyen and Dai Thi Xuan Trang and Motohiro Sasai and Takeshi Shiono and Tatsuo Oida and Shigeharu Harada and Kaeko Kamei},
  journal={Acta tropica},
  year={2007},
  volume={101 2},
  pages={130-8}
}
The formation of the malarial pigment, a unique hemozoin crystal with unit cells comprised of heme dimers, has been proposed as an ideal target for antimalarial screening. The mechanism of beta-hematin formation (a synthetic crystal structurally identical to hemozoin) has been suggested that a hydrophobic interaction is needed to solubilize heme, but this hypothesis needs further evidence. Direct study of the process of hemozoin formation in the malarial food vacuole has not been performed, due… CONTINUE READING
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