Alcoholic neuropathy

  title={Alcoholic neuropathy},
  author={Haruki Koike and Gen Sobue},
  journal={Current Opinion in Neurology},
Purpose of reviewThe concept of alcoholic neuropathy has been obscured because of an often undetected or overestimated influence of thiamine deficiency. We describe clinicopathologic features of alcoholic neuropathy, taking the effect of thiamine status into consideration, and recent progress associated with the pathogenesis. Recent findingsClinical features of alcoholic neuropathy without thiamine deficiency are characterized by slowly progressive, sensory-dominant symptoms. Superficial… 

Alcohol-Induced Neuropathy in Chronic Alcoholism: Causes, Pathophysiology, Diagnosis, and Treatment Options

This review focuses on the many pathways that play a role in the onset and development of alcohol-induced neuropathy, as well as present the possible treatment strategies of this disorder, providing insights into a further search of new treatment modalities.

Myelopathy and Neuropathy Associated With Alcoholism

  • H. Koike
  • Medicine, Psychology
    Neuroscience of Alcohol
  • 2019

The spectrum of clinicopathological features in pure autonomic neuropathy

The clinical and pathological features of pure autonomic neuropathy vary in terms of progression, autonomic involvement, presence of the antiganglionic acetylcholine receptor antibody, and loss of unmyelinated fibers.

Overview of symptoms, pathogenesis, diagnosis, treatment, and prognosis of various acquired polyneuropathies

Polyneuropathy in the axon is called distal axonopathy which is the result of interrupted function of the peripheral nerves and the most common response of neurons to metabolic or toxic disturbances, such as diabetes, kidney failure, connective tissue disease, deficiency syndrome, alcoholism, chemotherapy, and so on.

Main metabolic and toxic polyneuropathies in clinical practice

  • N. Pizova
  • Medicine, Psychology
    Meditsinskiy sovet = Medical Council
  • 2021
There is an assessment scale in points to determine the severity of diabetic polyneuropathy, which helps in clarifying the diagnosis and prognosis of the disease.

[Polyneuropathies in intestinal diseases].

Different aspects of polyneuropathies (PN) developed due to the deficit of group B vitamins in intestinal diseases are considered and possibilities of clinical and paraclinical diagnosis of these disorders are analyzed.

Diagnosis of sporadic transthyretin Val30Met familial amyloid polyneuropathy: a practical analysis

  • H. KoikeR. Hashimoto G. Sobue
  • Medicine, Psychology
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
  • 2011
Clinicians should consider the possibility of FAP ATTR Val30Met in patients presenting with neuropathy of undetermined etiology to avoid misdiagnosis in those without a family history of the disease.

Electrophysiological features of late-onset transthyretin Met30 familial amyloid polyneuropathy unrelated to endemic foci

Electrophysiological differences between late- and early-onset FAP TTR Met30 cases were present, probably reflecting the different underlying pathogenic mechanisms of neuropathy.

Alcohol-Related Neurologic Disorders: Ten Years of Experiences

Analysis of cases of alcoholrelated neurologic disorders among admitted patients that had been referred in Korea during the previous 10 years found 156 patients had the following diseases: Wernicke’…s encephalopathy, peripheral neuropathy, and alcoholic myopathy.

The epidemiology and risk factors of chronic polyneuropathy

More recent evidence suggests that the prevalence of polyneuropathy in the general population has increased over the years, and future research is necessary to confirm this increase in prevalence and to identify new and potentially modifiable risk factors.



Alcoholic neuropathy is clinicopathologically distinct from thiamine‐deficiency neuropathy

It is concluded that pure‐ form of alcoholic neuropathy (ALN) was distinct from pure‐form of thiamine‐deficiency neuropathy(TDN), supporting the view that alcoholic neuroopathy can be caused by direct toxic effect of ethanol or its metabolites.

Alcohol-related acute axonal polyneuropathy: a differential diagnosis of Guillain-Barré syndrome.

In 5 chronic alcoholics who developed ascending flaccid tetraparesis and areflexia within 14 days, the combination of alcohol abuse and malnutrition caused severe acute axonal polyneuropathy, and its distinction from Guillain-Barré syndrome is important.

Postgastrectomy polyneuropathy with thiamine deficiency

Thiamine deficiency should be considered in the differential diagnosis of motor-sensory polyneuropathy after gastrectomy, as various symptoms were seen in patients with postgastrectomy neuropathy.

The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy.

Clinopathological observations suggest that sensory ataxic, painful and perhaps trigeminal neuropathy are related to ganglioneuronopathic process, whereas multiple mononeuropathy and multiple cranial neuropathy would be more closely associated with vasculitic process.

Large and small fiber neuropathy in chronic alcohol‐dependent subjects

The findings indicate the direct toxic effect of alcohol on peripheral nerve fibers as the main etiologic factor of alcoholic PN.

Peripheral neuropathy in chronic alcoholism: a retrospective cross-sectional study in 76 subjects.

Alcohol-related neuropathy, especially when subclinical, seems to be frequent and mostly characterized by axonal degeneration of peripheral nerve fibres with earlier and more frequent involvement of sensory fibres and lower limbs.

Prognosis of alcoholic peripheral neuropathy.

The results suggest that the prognosis of alcoholic peripheral neuropathy is good and independent of age provided that intake of alcohol is discontinued and other causes of neuropathy are carefully excluded.

Dissociated sensation in amylidosis. Compound action potential, quantitative histologic and teased-fiber, and electron microscopic studies of sural nerve biopsies.

It is found that the various modalities of sensation were lost in the following order: temperature, pain, touch, and, finally, joint position, which is a unique feature of dominantly inherited amyloidosis.

Alcoholic neuropathy. An electrophysiological and histological study.