Alcoholic liver disease

  title={Alcoholic liver disease},
  author={Robert O’shea and Srinivasan Dasarathy and Arthur J. McCullough},
These recommendations provide a data-supported approach. They are based on the following: (1) formal review and analysis of the recently published world literature on the topic (Medline search); (2) American College of Physicians Manual for Assessing Health Practices and Designing Practice Guidelines1; (3) guideline policies, including the AASLD Policy on the development and use of Practice Guidelines and the American Gastroenterological Association Policy Statement on Guidelines2; and (4) the… 

Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic Review.

A systematic review of clinical characteristics and genomics associated with the risk of alcoholic hepatitis found an unmet need for noninvasive biomarkers for the diagnosis, and predicting prognosis and response to therapy.

Management of alcohol‐related liver disease: the French Association for the Study of the Liver and the French Alcohol Society clinical guidelines

  • A. LouvetJ. Trabut B. Rolland
  • Medicine
    Liver international : official journal of the International Association for the Study of the Liver
  • 2022
The French Association for the Study of the Liver wished to organise guidelines together with the French Alcohol Society in order to summarise the best evidence available about several key clinical points in ARLD.

Controversies in clinical trials for alcoholic hepatitis.

Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary, and Renal Considerations

Multidisciplinary international experts were able to formulate evidence-based recommendations for the management acute or acute on chronic liver failure in the ICU, acknowledging that most recommendations were based on low-quality indirect evidence.

Assessment of the value of gastroenterologists’ activity in the outpatient setting: applying the “Moneyball” approach to clinical care

Measurement of the value of clinical activity represents an important component of gastroenterologists’ performance and there was a threefold variation among physician levels of value with more experienced clinicians demonstrating higher value levels.

Practical Concerns and Controversies in the Management of Alcoholic Hepatitis.

This review addresses 4 key controversies and other practical issues associated with the diagnosis, prognosis, management, and treatment of patients with AH.


The article suggests that, more research should be carried out in therapeutic management of alcoholic liver disease.

Recent updates on alcoholic hepatitis.

  • Lindsey C. ShipleyS. KodaliA. Singal
  • Medicine
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2019



Standardized Reporting of Clinical Practice Guidelines: A Proposal from the Conference on Guideline Standardization

The Conference on Guideline Standardization (COGS) was convened to define a standard for guideline reporting that would promote guideline quality and facilitate implementation, and provided a checklist of components necessary for evaluation of validity and usability.

Is alcoholic hepatitis an indication for transplantation? Current management and outcomes

  • P. Mathurin
  • Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2005
A reasonable approach would be to carry out only pilot studies on only a small cohort of patients to determine whether transplantation improves survival in patients with severe AH.

A systematic review of the diagnostic accuracy of physical examination for the detection of cirrhosis

Physical findings are generally of low sensitivity for the diagnosis of cirrhosis, and signs with higher specificity represent decompensated disease, and most studies have been undertaken in highly selected populations.

Glucocorticoids are ineffective in alcoholic hepatitis: a meta-analysis adjusting for confounding variables.

The results do not support the routine use of glucocorticoids in patients with alcoholic hepatitis, including those with encephalopathy, but whether other subgroups may benefit needs further investigation using the individual patient data from the published trials and testing in new randomised trials.

Alcoholic hepatitis: from pathogenesis to treatment

The current state in diagnosis and management of alcoholic hepatitis is summarized and the latest advances in pathophysiology that may lead to new therapeutic strategies for this difficult clinical condition are reviewed.

The rational clinical examination.

It is shown that in the case of possible ascites in an alcoholic patient cited by Sackett, if a physician is 90% sure that the patient does not have ascites based on his clinical acumen and does not order a confirmatory test, he may be held accountable for complications of that problem if his diagnosis is wrong.

Appropriateness of liver biopsy.

It is concluded that liver biopsy is used extensively, but its appropriateness has not been evaluated perfectly, and further evaluation of theappropriateness of liver biopsies in the practical algorithm of such diseases is needed.

Treatment of alcoholic hepatitis.