Alcoholic liver disease: pathogenesis, management, and novel targets for therapy.

  title={Alcoholic liver disease: pathogenesis, management, and novel targets for therapy.},
  author={Eric S. Orman and Gemma {\`O}dena and Ram{\'o}n Bataller},
  journal={Journal of gastroenterology and hepatology},
  volume={28 Suppl 1},
Alcohol use is a leading cause of preventable morbidity and mortality worldwide, with much of its negative impact as the result of alcoholic liver disease (ALD). ALD is a broad term that encompasses a spectrum of phenotypes ranging from simple steatosis to steatohepatitis, progressive fibrosis, cirrhosis, and hepatocellular carcinoma. The mechanisms underlying the development of these different disease stages are incompletely understood. Standard treatment of ALD, which includes abstinence… CONTINUE READING
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